Catha edulis (khat) induces apoptosis in Madin-Darby bovine kidney cell line
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منابع مشابه
Catha edulis (khat) Induces Apoptosis in Madin-Darby Bovine Kidney Cell Line
BACKGROUND Khat (Catha edulis) is a controversial plant having a euphoretic effect, at the same time part of culture in many countries such as Africa and Arabian Peninsula. The presence of amphetamine-like substance, cathinone and cathine make this plant banned in many countries. Many neurological and other system related studies have been carried out in this plant, but the lack of toxicity stu...
متن کاملMadin-Darby Canine Kidney Epithelial Cell Line
The Madin-Darby canine kidney (MDCK) cell line, derived from distal tubule/ collecting duct, expresses differentiated properties of renal tubule epithelium in culture. We studied the expression of adrenergic receptors in MDCK to examine the role of catecholamines in the regulation of renal function. Radioligand-binding studies demonstrated, on the basis of receptor affinities of subtype-selecti...
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Khat chewing is widely practiced in Eastern Africa and the Middle East. Khat is genotoxic to cells within the oral mucosa, and several studies have suggested an association between khat use and oral lesions like hyperkeratosis and oral cancer. This study investigated the mechanism of khat-induced cytotoxicity using primary normal human oral keratinocytes (NOK) and fibroblasts (NOF). Khat induce...
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Severe rhabdomyolysis is a rare complication of exposure to the recreational drug khat. Adverse reactions to khat that have been reported in the literature include myocardial infarction and reversible vasoconstriction syndrome. The active ingredient, cathinone, is a naturally occurring beta-ketone amphetamine that may be responsible for this severe catecholaminergic response. Here we report a c...
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ژورنال
عنوان ژورنال: Pharmacognosy Magazine
سال: 2016
ISSN: 0973-1296
DOI: 10.4103/0973-1296.191456